Sanitary and industrial pumping and metering systems
UF, MF, and TFF systems
Fabrications using specialty alloys and composite materials for aggressive precursor chemicals
Sanitary process carts and laboratory process equipment
Clean-in-Place / Steam-in-Place options
Liquid ring vacuum systems
Pharmaceutical Pilot Plant Modules
Wide Range of Custom Engineered Projects
Whatever your newest challenge is for pharmaceutical processing,
we welcome the opportunity to discuss it with you.
A U.S.-based pharmaceutical contract manufacturer needed to increase production of precursor chemicals in one of its manufacturing facilities. The company turned to ProFlow for help, knowing that that this effort required a supplier with experience in the development of scaled-up fluid processing systems with complex characteristics.
As is often the case with pharmaceutical precursors, the chemicals were volatile and dangerous, needing to be handled safely and metered precisely to match the customer requirements. An added challenge was presented by the fact that there were significant space constraints where the system was to be housed, limiting the size of the installed skid.
ProFlow engineers worked with the customer to design the system, specify components and materials, and fabricate the finished system. Our experienced engineering staff teamed with our fabrications group (supported by the company’s extensive fabrication certifications) to tackle this project. Adding to the complexity of this project was the requirement to meter-in two aggressive chemicals at an accuracy of +/- 1%. The system also had to be built to cGMP requirements.
Additionally, since the customer required FDA approval, ProFlow provided the material certifications, calibration certificates, and surface finish certificates necessary to obtain that approval.
The final system was designed and built to best meet the requirements of the application and included 316 polished stainless steel frames and Hastelloy C276 pumps and piping, along with other specialized pumps. The system was also equipped with the complex instrumentation and controls required to operate the system. All items were built to the requirements for an explosion-proof application.
Key components include: